Genetic sequencing and analysis for cancer is a time in life when more is better. CancerPOP uses a new strategy that utilizes your individual DNA and powerful computer mapping to construct three-dimensional models of the disease and the response to treatments.
At CancerPOP, we go deeper into your genetic makeup to provide a more complete picture of your cancer. Other companies look at hundreds of genes, while we perform whole exome sequencing (WES) – meaning we look at the protein-coding region of your individual genome (all the DNA inside a cell) -- from your tumor specimen. We are pulling from genomic data on approximately 20,000 genes – not just hundreds.
Once the DNA sequencing is complete, we input the genomic data into a computer modeling software, which examines and matches multi-gene variants to multi-treatment in order to create a three-dimensional map of your cancer. Using this highly detailed roadmap, we can predict drug response to standard of care drugs with high accuracy. This method can identify drug combinations that are tailored to your specific cancer as well as explain why a drug does or does not work.
What is Whole Exome Sequencing?
Exome sequencing or Whole Exome Sequencing (WES), is a sequencing technique which identifies the protein-coding genes in a genome (known as the exome). The majority of variations that may cause a genetic disorder are found in this region. WES identifies genetic variants that affect the protein function of the genes giving us a more detailed information of your cancer.
How is Whole Exome sequencing (WES) different than Whole Genome Sequencing (WGS)?
Whole Exome Sequencing (WES) identifies genetic variants that alter the protein sequences. Proteins are the workhorse in the body’s cells. Focusing on the protein-coding allows for modeling of the upstream and downstream effects of Standard-of-Care drugs on variations found in your DNA.
Whole Genome Sequencing (WGS) looks at an entire gene, therefore is more cost prohibitive and time consuming. Because Whole Genome Sequencing is data rich, this method is typical ran using targeted gene panels resulting in less DNA coverage.
Using WES we are able to look at over 20,000 genes - compared to only hundreds using other genetic testing methods - giving you a more complete analysis of your DNA.
Why is Whole Exome Sequencing (WES) a powerful approach to looking at your DNA information?
Because Whole Exome Sequencing looks at the details of the protein, we can utilize powerful computer modeling to map the upstream and downstream effects of treatments on your DNA variants. Whole Exome Sequencing looks more completely at your DNA compared to other genetic tests. The result is a higher yield of relevant variants from Whole Exome Sequencing.
Where can I learn more?
You can learn more about this process by speaking to one of our specialists. Please contact us with any questions on how the process works or to see if our program is right for you.